Insubolic
Insubolic is a liquid that contains man-made insulin-like growth factor-1 (IGF-1). Stimulated by growth hormone and produced primarily in the liver, it binds to the IGF-1 receptor with a high affinity and to the insulin receptor with a much lower affinity. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone & cartilage tissue. Insubolic comes as a solution in a vial, ready for injection.
The Growth Hormone/IGF axis consists of IGF-1, IGF-2 and several high and low affinity IGF Binding Proteins (IGFBP). The whole system is tightly regulated by a feedback loop involving Growth Hormone (GH) secreted by the pituitary, and GH production and secretion controlled by Growth Hormone Releasing Hormone (GHRH) at the hypothalamus.
IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development. IGF-1 is synthesized mainly by the liver but also locally in many tissues. In contrast to many other peptide hormones, IGFs are avidly bound to specific IGFBPs, which significantly increases the half-life of IGF-1 in circulation.The seven classes of IGFBPs which are known at present either bind IGF-1 and IGF-2 with similar affinities or show a preference for IGF-2. The predominant IGFBP is IGFBP-3, which binds not only IGF-1 but also the Acid-labile Subunit (ALS). Thus, most of the IGF-1 in circulation is bound within this ternary complex.
Do not use Insubolic If you are allergic to somatropin, to phenol, NaCl, Benzyl Benzoate.
Insubolic concentration and dosing
1 ml of solution contains: 1 mg (1000 mcg) IGF-1.Insubolic 5 mg (5000 mcg)/5 ml solution for injection in vial
How to store Insubolic
Store unused Insubolic vials in a refrigerator(2°C – 8°C) 35° -46° F. Do not Freeze. Do not shake.